September 2013 – Naprogenix has been awarded from NIAAA SBIR Phase 2 Grant entitled “Selection-driven plant metabolites for treatment of CNS diseases”.

Project Background: Plants are a major source of existing medicines, but the pharmaceutical industry has now almost abandoned this source in favor of synthetic chemicals. One reason is that plant metabolites are often too complex for synthetic methods to be used for their modification or production. The technology being developed by Naprogenix uses the plants own biosynthetic capacity to modify the active chemicals contained in the plant. It is also capable of increasing the amounts of the active chemicals that are present. The “directed evolution” of a plant species using this technology is capable of generating novel compounds that may be of value in many CNS diseases, for example the targets in this project are important in drug dependence and neurodegenerative disease.

July 2013 – Naprogenix has received a KY Matching Funds Award entitled “Accelerated implementation of Commercialization Plan for Novel Pharmacotherapies for Alcoholism”. This proposal is to extend the research to improve the potential value of the products in alcoholism.

March 2013 – NIAAA awards Naprogenix a SBIR Phase 2 Contract entitled “Novel Pharmacotherapies for Alcoholism”. The objective of phase II of the SBIR Contract is to evaluate four lead compounds as treatments for alcoholism.

January 2013 – Terry Minton becomes the full-time CEO of Solidagex and Dr. John Littleton assumes the role as CEO of Naprogenix.

September 2012 - NIAAA awards Naprogenix a SBIR Phase 1 Contract entitled “Novel Pharmacotherapies for Alcoholism”. The project aims to discover new drug or nutritional approaches to the treatment of alcoholism. This condition is common and devastating, with relatively ineffective current treatment. The project therefore has the potential for great therapeutic and commercial application.

June 2011 – Naprogenix announces the spin off of Solidagex, a new company to commercialize to promote native goldenrod-based products. Research & Development performed by Naprogenix on its native plant extract library identified a native goldenrod species as containing novel valuable activity in flavonoid-rich extracts from this species. Terry Minton will become the CEO of Solidagex. Solidagex will be raising private capital to begin commercial operation to produce goldenrod extract for incorporation into existing and new products through contracts in pet food, cosmetic, and nutraceutical companies in the market.. Naprogenix intends to follow a similar commercialization plan for other products that are identified in wild type plant extracts in its library.

Naprogenix, Inc. is a research and development company focused on identifying valuable bioactivity in native plants to produce extracts or chemical compounds of commercial interest.
Website: www.naprogenix.com

Solidagex, Inc. produces natural extracts from Kentucky's native goldenrod plant for use as bioactive ingredients in the nutrition, cosmetics and Ag-bio industries. Solidagex offers customers the opportunity to derive multiple benefits from one source of proprietary ingredients.
Website: www.solidagex.com

April 2011 – Naprogenix researchers’ findings entitled “Natural Products Genomics: A Novel Approach for the Discovery of Anti-Cancer Therapeutics” are published in Journal of Pharmacological and Toxicological Methods

Article title: Natural Products Genomics: A Novel Approach for the Discovery of Anti-Cancer Therapeutics
Authors: N.R. Monks, B. Li, S. Gunjan, D.T. Rogers M. Kulshresthaa, D.L. Falcone, and J.M. Littleton
Reference: JPM5987
Journal title: Journal of Pharmacological and Toxicological Methods
Website: http://www.sciencedirect.com/science/article/pii/S1056871911002371



September 2010 - Minton Named Naprogenix CEO - Naprogenix, Inc., a drug discovery and plant biotechnology company based on University of Kentucky and proprietary intellectual property, announced today that it has appointed Terry Minton to be its CEO, effective immediately.

Minton, a Louisville resident with a wealth of experience in the healthcare and biotechnology industries, is best known for his having launched the cancer therapeutics company Aptamera with Dr. Donald M. Miller, Director of the James Graham Brown Cancer Center. Amidst the economic disruption wrought by the events of September 11, 2001, Minton raised several million dollars in angel and venture funding and positioned the company for its acquisition by the British pharmaceutical company Antisoma PLC.

Minton has held CEO and other leadership positions with various companies in the healthcare technology and biotechnology sector. Additionally, he spearheaded the development of high-value intellectual properties at the Innovation Center for a Kentucky-based Fortune 100 health benefits provider.

“Terry Minton is the perfect fit to lead Naprogenix – an experienced biotech CEO who has raised millions in equity capital and formed alliances with global companies capable of taking products created by the Naprogenix technology platform into worldwide distribution,” said John M. Littleton, M.D., PhD., Chief Scientific Officer and Co-Founder of Naprogenix.

“Not only does Terry Minton understand this space, he has a consistent track record of delivering in fundraising, product development and intellectual property licensing and other monetization activities,” added Littleton, who had been serving as interim CEO until a nationwide search for a replacement led Naprogenix to Minton.

Naprogenix is the recipient of over $6 million in National Institutes of Health (NIH) Small Business Innovation Research (SBIR) and Small Business Technology Transfer Research (STTR) funding, as well as support from the Kentucky Science and Technology Corporation, and is the exclusive licensee of patented technology owned by the University of Kentucky Research Foundation, Inc.

Naprogenix’s technology harnesses the power of plant metabolism by subjecting native and engineered plant extracts to high-throughput pharmacological screening to discover novel, patentable structures and activities useful for the treatment of neurodegenerative diseases, cancer, age-related macular degeneration, and other chronic diseases. Certain of the natural products are also useful as all-natural pesticides.

Minton will serve as President/CEO and Chairman of the Board of Directors of Naprogenix and is expected to focus initial efforts on accelerating product development along with consummation of strategic alliances with global healthcare, nutritional and personal care products companies.

July 2007 - KY SBIR/STTR Matching Funds Press Release
Naprogenix was one of twenty companies that were recipients of KY SBIR/STTR Matching Funds. In honor of these twenty companies, Kentucky’s Governor Ernie Fletcher and Commissioner for Department of Commercialization and Innovation Deborah Clayton ceremoniously awarded $1.875 million dollar check to all the representatives of the funded companies. Naprogenix received KY matching funds for our National Cancer Institute Phase I STTR on Novel estrogen receptor ligands from plant genomic. Both the Louisville Courier Journal and Lexington Herald Leader newspapers recognized Naprogenix as one of the awardees of this funding from the KY State Government.

July 2007 - National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded Fast-Track STTR Grant on “Hypericum extracts as potential anti-relapse medications in alcoholism”

June 2007 - National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded Phase II STTR Grant on “Transgenic plant cells as a source of hepatoprotective drugs”

May 2007 - John M. Littleton, MD, PhD (Chief Biomedical Science Officer) published an article titled “The future of plant drug discovery”in Expert Opinion on Drug Discovery, May 2007, Vol. 2, No. 5, Pages 673-683. Please visit Expert Opinion Website at
http://www.expertopin.com/toc/edc/2/5
to obtain copies of Dr. Littleton’s article.

May 2007 – Deane L. Falcone, PhD (Chief Molecular Science) represented Naprogenix at BIO 2007 conference in Boston, MA. Dr. Falcone presented a poster on “A novel integrated strategy for plant drug discovery based on high throughput pharmacological screening (HTPS) and plant genomics”


January 2007 – Lexington Venture Club recognizes Naprogenix as one of the regional, early-stage companies that received funding in 2006.

Fall 2006 – Naprogenix was featured in the University of Kentucky College of Agriculture “the Magazine” article titled “Biotechnology – Moving Beyond the Lab”.

August 2006 - National Cancer Institute (NCI) awarded Phase I STTR Grant on “Novel estrogen receptor ligands from plant genomics”

January 2006 – Dr. Deane Falcone and Dr. John Littleton were awarded United States Patent 6,989,236 titled “Methods to identify plant metabolites”.

January 2006 – Kentucky Science & Technology Corporation awarded R&D Voucher on “Novel Active Insecticidal Compounds from Kentucky Native Plants”

Spring 2006 – The Lane Report’s Magazine featured Naprogenix in their annual “Research Kentucky”report.

Spring 2006 – Kentucky AgriTechnology Magazine featured Naprogenix in the article titled “Natural Products Research = New Crops for Kentucky Farms”

January 2005 – Kentucky Science & Technology Corporation awarded R&D Voucher on “Application of NPG Technology to Alternate Plant Species”

September 2004 – National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded Phase I STTR Grant on “Potential anti-relapse drugs: a plant genomics approach”

June 2004 – National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded Phase I STTR Grant on “Application of plant genomics to alcoholic brain damage”

September 2003 – National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded Phase I STTR Grant on “Transgenic plant cells as a source of hepatoprotective drugs”

2003 –Naprogenix obtains the exclusive license agreement with the University of Kentucky on patented NPG technology.